Amitriptyline potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Avoid or use an alternative medication. Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking the reuptake of NA or by blocking the uptake of indirect sympathomimetics in the adrenergic neuron.
Amoxapine potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Avoid or use an alternative medication. Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking the reuptake of NA or by blocking the uptake of indirect sympathomimetics in the adrenergic neuron.
Cabergolines, Pseudoephedrine. Mechanism: pharmacodynamic synergism. contraindicated additional vasospasm; risk of high blood pressure.
Clomipramine potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Avoid or use an alternative medication. Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking the reuptake of NA or by blocking the uptake of indirect sympathomimetics in the adrenergic neuron.
Topical cocaine increases the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Avoid or use an alternative medication.
Desipramine potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Avoid or use an alternative medication. Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking the reuptake of NA or by blocking the uptake of indirect sympathomimetics in the adrenergic neuron.
Desvenlafaxine potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Avoid or use an alternative medication.
Doxapram potentiates the effects of pseudoephedrine through pharmacodynamic synergism. Avoid or use an alternative medication. Additive pressor effect.
Doxepin potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Avoid or use an alternative medication. Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking the reuptake of NA or by blocking the uptake of indirect sympathomimetics in the adrenergic neuron.
Duloxetine potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Avoid or use an alternative medication.
Imipramine potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Avoid or use an alternative medication. Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking the reuptake of NA or by blocking the uptake of indirect sympathomimetics in the adrenergic neuron.
Pseudoephedrine decreases the effect of iobenguan I 123 through receptor binding competition. Avoid or use an alternative medication. If clinically appropriate, withhold drugs that compete for NE receptor sites for at least 5 half-lives; may lead to false negative imaging results. Do not administer pseudoephedrine for at least 7 days after each dose of iobenguan.
Pseudoephedrine decreases the effect of iobenguan I 131 through receptor binding competition. Avoid or use an alternative medication. If clinically appropriate, withhold drugs that compete for NE receptor sites for at least 5 half-lives; may lead to false negative imaging results. Do not administer pseudoephedrine for at least 7 days after each dose of iobenguan.
Isoflurane increases the toxicity of pseudoephedrine by mechanism: unknown. Avoid or use an alternative medication. Risk of Vtachycardia, AHT.
Levomilnacipran potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Avoid or use an alternative medication.
lofepramine, pseudoephedrine. Other (see comment). Avoid or use an alternative medication. Comment: Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking NE reuptake or by blocking the uptake of indirect sympathomimetics into the adrenergic neuron.
maprotiline, pseudoephedrine. Other (see comment). Avoid or use an alternative medication. Comment: Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking NE reuptake or by blocking the uptake of indirect sympathomimetics into the adrenergic neuron.
Methoxyflurane increases the toxicity of pseudoephedrine by mechanism: unknown. Avoid or use an alternative medication. Risk of Vtachycardia, AHT.
Milnacipran potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Avoid or use an alternative medication.
Nortriptyline potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Avoid or use an alternative medication. Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking the reuptake of NA or by blocking the uptake of indirect sympathomimetics in the adrenergic neuron.
Ozanimod increases the toxicity of pseudoephedrine through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Avoid or use an alternative medication. Because the active metabolite of ozanimod is an inhibitor of MAO-B in vitro, the potential for serious adverse reactions, including hypertensive crisis, exists. Therefore, the concomitant use of ozanimod with medicinal products that may increase norepinephrine or serotonin is not recommended. With simultaneous use, pay attention to high blood pressure.
Protriptyline potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Avoid or use an alternative medication. Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking the reuptake of NA or by blocking the uptake of indirect sympathomimetics in the adrenergic neuron.
Sevoflurane increases the toxicity of pseudoephedrine by mechanism: unknown. Avoid or use an alternative medication. Risk of Vtachycardia, AHT.
trazodone, pseudoephedrine. Other (see comment). Avoid or use an alternative medication. Comment: Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking NE reuptake or by blocking the uptake of indirect sympathomimetics into the adrenergic neuron.
Trimipramine potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Avoid or use an alternative medication. Tricyclic antidepressants increase or decrease the effects of sympathomimetics by blocking the reuptake of NA or by blocking the uptake of indirect sympathomimetics in the adrenergic neuron.
Venlafaxine potentiates the effects of pseudoephedrine through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Avoid or use an alternative medication.
Acetazolamide increases the level or effect of pseudoephedrine through passive renal tubular reabsorption - alkaline urine. Use caution/monitoring.
Both albuterol and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Pseudoephedrine decreases the effects of alfuzosin through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Use caution/monitoring.
Aluminum hydroxide increases the level or effect of pseudoephedrine through passive renal tubular reabsorption - alkaline urine. Use caution/monitoring. Caution with frequent or high-dose antacids
Ammonium chloride decreases the effects of pseudoephedrine by an unknown mechanism. Use caution/monitoring. Urinary excretion of indirect-acting alpha/beta agonists (eg, pseudoephedrine) may be increased when co-administered with urinary acidifiers, resulting in lower serum concentrations.
Both arformoterol and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Benzphetamine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
bromocriptine, pseudoephedrine. One potentiates the action of the other through pharmacodynamic synergism. Use caution/monitoring. Hypertension, Tac V.
chlorpromazine, pseudoephedrine. Mechanism: unknown. Use caution/monitoring. Consider avoiding the use of pseudoephedrine in patients receiving phenothiazines (particularly thioridazine) due to the potential risk of cardiac arrhythmia or sudden death. With concurrent use, watch for signs of ventricular arrhythmias.
Both dexfenfluramine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Use caution/monitoring.
Both dexmethylphenidate and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both dextroamphetamine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Diethylpropion and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Dobutamine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both dopamine and pseudoephedrine increase sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both dopexamine and pseudoephedrine increase sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Pseudoephedrine decreases the effects of doxazosin through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Use caution/monitoring.
Both pseudoephedrine and droxidopa increase sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring. Lying down may increase risk of high blood pressure
Both ephedrine and pseudoephedrine increase sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.ephedrine, pseudoephedrine. Both potentiate the action of the other through pharmacodynamic synergism. Use caution/monitoring.
Both epinephrine and pseudoephedrine increase sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
pseudoephedrine, inhaled epinephrine. One potentiates the effects of the other through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both racemic epinephrine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Use caution/monitoring.
Intranasal esketamine, pseudoephedrine. One increases the toxicity of the other through sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use caution/monitoring. Blood pressure should be closely monitored when esketamine nasal is used concomitantly with stimulants. .
Fenfluramine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
fluphenazine, pseudoephedrine. Mechanism: unknown. Use caution/monitoring. Consider avoiding the use of pseudoephedrine in patients receiving phenothiazines (particularly thioridazine) due to the potential risk of cardiac arrhythmia or sudden death. With concurrent use, watch for signs of ventricular arrhythmias.
Both formoterol and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
hydralazine, pseudoephedrine. Mechanism: pharmacodynamic antagonism. Use caution/monitoring. Sympathomimetics may antagonize the activity of some antihypertensive agents.
Pseudoephedrine decreases the effect of insulin degludec through pharmacodynamic antagonism. Modify/closely monitor therapy. Sympathomimetics increase blood sugar by stimulating alpha and beta receptors; This effect results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion.
Pseudoephedrine decreases the effect of insulin degludec/insulin aspart through pharmacodynamic antagonism. Modify/closely monitor therapy. Sympathomimetics increase blood sugar by stimulating alpha and beta receptors; This effect results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion.
Pseudoephedrine decreases the effect of insulin detemir through pharmacodynamic antagonism. Modify/closely monitor therapy. Sympathomimetics increase blood sugar by stimulating alpha and beta receptors; This effect results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion.
Pseudoephedrine decreases the effect of insulin glargine through pharmacodynamic antagonism. Modify/closely monitor therapy. Sympathomimetics increase blood sugar by stimulating alpha and beta receptors; This effect results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion.
Pseudoephedrine decreases the effect of inhaled insulin through pharmacodynamic antagonism. Modify/closely monitor therapy. Sympathomimetics increase blood sugar by stimulating alpha and beta receptors; This effect results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion.
Pseudoephedrine decreases the effect of regular human insulin through pharmacodynamic antagonism. Modify/closely monitor therapy. Sympathomimetics increase blood sugar by stimulating alpha and beta receptors; This effect results in increased hepatic glucose production, glycogenolysis, and decreased insulin secretion.
Both isoproterenol and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both levalbuterol and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Lisdexamfetamine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both metaproterenol and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both methamphetamine and pseudoephedrine increase sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Methenamine decreases the effects of pseudoephedrine by an unknown mechanism. Use caution/monitoring. Urinary excretion of indirect-acting alpha/beta agonists (eg, pseudoephedrine) may be increased when co-administered with urinary acidifiers, resulting in lower serum concentrations.
Methyldopa potentiates the effects of pseudoephedrine by an unknown mechanism. Use caution/monitoring.
Methylenedioxymethamphetamine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Midodrine and pseudoephedrine increase sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Pseudoephedrine decreases the effect of nateglinide through pharmacodynamic antagonism. Use caution/monitoring. Concomitant use may reduce the hypoglycemic effect of nateglinide.
Both norepinephrine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both inhaled pseudoephedrine and olodaterol increase sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring. Caution with concomitant administration of adrenergic drugs due to additive sympathetic effects
Oxytocin potentiates the effects of pseudoephedrine through pharmacodynamic synergism. Use caution/monitoring.
perphenazine, pseudoephedrine. Mechanism: unknown. Use caution/monitoring. Consider avoiding the use of pseudoephedrine in patients receiving phenothiazines (particularly thioridazine) due to the potential risk of cardiac arrhythmia or sudden death. With concurrent use, watch for signs of ventricular arrhythmias.
Both phendimetrazine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both phentermine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Phenylephrine and pseudoephedrine increase sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both oral phenylephrine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both pirbuterol and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Potassium phosphate decreases the effects of pseudoephedrine by an unknown mechanism. Use caution/monitoring. Urinary excretion of indirect-acting alpha/beta agonists (eg, pseudoephedrine) may be increased when co-administered with urinary acidifiers, resulting in lower serum concentrations.
prochlorperazine, pseudoephedrine. Mechanism: unknown. Use caution/monitoring. Consider avoiding the use of pseudoephedrine in patients receiving phenothiazines (particularly thioridazine) due to the potential risk of cardiac arrhythmia or sudden death. With concurrent use, watch for signs of ventricular arrhythmias.
promazine, pseudoephedrine. Mechanism: unknown. Use caution/monitoring. Risk of cardiac arrhythmias or sudden death, more likely with thioridazine than with other phenothiazines. Interaction more likely in certain predisposed patients. only.
promethazine, pseudoephedrine. Mechanism: unknown. Use caution/monitoring. Risk of cardiac arrhythmias or sudden death, more likely with thioridazine than with other phenothiazines. Interaction more likely in certain predisposed patients. only.
Both propylhexedrine and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both pseudoephedrine and safinamide potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring. Monitor patients for hypertension when safinamide is prescribed in conjunction with prescription or over-the-counter sympathomimetics, including nasal, oral, or ophthalmic decongestants, and cold medications.
Both salmeterol and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Both serdexmethylphenidate/dexmethylphenidate and pseudoephedrine reduce sedation. Use caution/monitoring.Serdexmethylphenidate/dexmethylphenidate and pseudoephedrine increase sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Use caution/monitoring.
Pseudoephedrine decreases the effects of silodosin through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Use caution/monitoring.
Sodium bicarbonate increases the level or effect of pseudoephedrine through passive renal tubular reabsorption - alkaline urine. Use caution/monitoring. Caution with frequent or high-dose antacids
Sodium citrate/citric acid increases the level or effect of pseudoephedrine via passive renal tubular reabsorption - alkaline urine. Use caution/monitoring.
Sodium lactate increases the level or effect of pseudoephedrine through passive renal tubular reabsorption - alkaline urine. Use caution/monitoring.
Sodium phosphate, IV decreases the effects of pseudoephedrine by an unknown mechanism. Use caution/monitoring. Urinary excretion of indirect-acting alpha/beta agonists (eg, pseudoephedrine) may be increased when co-administered with urinary acidifiers, resulting in lower serum concentrations.
Both pseudoephedrine and solriamfetol potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Spironolactone reduces the effect of pseudoephedrine through pharmacodynamic antagonism. Use caution/monitoring.
Pseudoephedrine decreases the effects of tamsulosin through sympathetic (adrenergic) effects, including increased blood pressure and increased heart rate. Use caution/monitoring.
Pseudoephedrine decreases the effects of terazosin through sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
Terbutaline and pseudoephedrine potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.
thioridazine, pseudoephedrine. Mechanism: unknown. Use caution/monitoring. Consider avoiding the use of pseudoephedrine in patients receiving phenothiazines (particularly thioridazine) due to the potential risk of cardiac arrhythmia or sudden death. With concurrent use, watch for signs of ventricular arrhythmias.
trifluoperazine, pseudoephedrine. Mechanism: unknown. Use caution/monitoring. Consider avoiding the use of pseudoephedrine in patients receiving phenothiazines (particularly thioridazine) due to the potential risk of cardiac arrhythmia or sudden death. With concurrent use, watch for signs of ventricular arrhythmias.
Pseudoephedrine and xylometazoline potentiate sympathetic (adrenergic) effects, including increases in blood pressure and heart rate. Use caution/monitoring.